OR31-05 Emergence of Ovarian Hyperandrogenism and Luteal Insufficiency Following ESR1 Knockdown in the Mediobasal Hypothalamus of Adult Female Rhesus Monkeys

Diminished estradiol (E2) negative feedback action by neuronal ESR1 in the arcuate nucleus (ARC) of the mediobasal hypothalamus (MBH) is hypothesized to cause gonadotropin-releasing hormone (GnRH) hypersecretion, and thus LH excess, contributing to ovarian hyperandrogenism in polycystic ovary syndro...

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Vydáno v:J Endocr Soc
Hlavní autoři: Levine, Jon E, Greinwald, Emily P, Felton, Jesi A, Flowers, Matthew T, Willging, Molly M, Shapiro, Robert A, Keen, Kim L, Terasawa, Ei, Uhlrich, Daniel J, Abbott, David Howard
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2020
Témata:
Reproductive Endocrinology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7207541/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/jendso/bvaa046.1320
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