SUN-672 SGLT2 Inhibitor Reduces Hyperinsulinemia and Restores Pulsatile Growth Hormone Secretion in Obese MC4RKO Mice

Insulin and growth hormone (GH) are crucial counter-regulatory hormones in regulating glucose and lipid metabolisms. Insulin promotes fat storage, while GH promotes lipolysis and fat oxidation. In obese individuals, reduced GH secretion (hyposomatotropism) and increased insulin secretion (hyperinsul...

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Detalhes bibliográficos
Publicado no:J Endocr Soc
Main Authors: Huang, Zhengxiang, Huang, Lili, Wang, Chengjian, Zhu, Shanli, Qi, Xinzhou, Chen, Yang, Zhang, Yanjun, Cowley, Michael A, Veldhuis, Johannes D, Chen, Chen
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2020
Assuntos:
Diabetes Mellitus and Glucose Metabolism
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7207352/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/jendso/bvaa046.1158
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