SUN-672 SGLT2 Inhibitor Reduces Hyperinsulinemia and Restores Pulsatile Growth Hormone Secretion in Obese MC4RKO Mice

Insulin and growth hormone (GH) are crucial counter-regulatory hormones in regulating glucose and lipid metabolisms. Insulin promotes fat storage, while GH promotes lipolysis and fat oxidation. In obese individuals, reduced GH secretion (hyposomatotropism) and increased insulin secretion (hyperinsul...

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Dades bibliogràfiques
Publicat a:J Endocr Soc
Autors principals: Huang, Zhengxiang, Huang, Lili, Wang, Chengjian, Zhu, Shanli, Qi, Xinzhou, Chen, Yang, Zhang, Yanjun, Cowley, Michael A, Veldhuis, Johannes D, Chen, Chen
Format: Artigo
Idioma:Inglês
Publicat: Oxford University Press 2020
Matèries:
Diabetes Mellitus and Glucose Metabolism
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7207352/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/jendso/bvaa046.1158
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