LMBR1L regulates lymphopoiesis through Wnt/β-catenin signaling

Precise control of Wnt signaling is necessary for immune system development. Here we detected severely impaired development of all lymphoid lineages in mice resulting from a N-ethyl-N-nitrosourea-induced mutation in limb region 1 like (Lmbr1l), encoding a membrane-spanning protein with no previously...

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Pubblicato in:Science
Autori principali: Choi, Jin Huk, Zhong, Xue, McAlpine, William, Liao, Tzu-Chieh, Zhang, Duanwu, Fang, Beibei, Russell, Jamie, Ludwig, Sara, Nair-Gill, Evan, Zhang, Zhao, Wang, Kuan-wen, Misawa, Takuma, Zhan, Xiaoming, Choi, Mihwa, Wang, Tao, Li, Xiaohong, Tang, Miao, Sun, Qihua, Yu, Liyang, Murray, Anne R., Moresco, Eva Marie Y., Beutler, Bruce
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2019
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7206793/
https://ncbi.nlm.nih.gov/pubmed/31073040
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aau0812
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