Dynein light chain binding determines complex formation and posttranslational stability of the Bcl-2 family members Bmf and Bim

The BH3-only class of Bcl-2 family proteins triggers mitochondrial apoptosis. Several mechanisms are used to restrain the pro-apoptotic activity of these proteins. Dynein light chain (DYNLL) 1 and 2 has been proposed to negatively regulate the activity of Bim and Bmf, respectively, and the Bim–DYNLL...

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Pubblicato in:Cell Death Differ
Autori principali: Singh, Prafull Kumar, Roukounakis, Aristomenis, Weber, Arnim, Das, Kushal Kumar, Sohm, Benedicte, Villunger, Andreas, Garcia-Saez, Ana J., Häcker, Georg
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group UK 2019
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7206095/
https://ncbi.nlm.nih.gov/pubmed/31189926
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41418-019-0365-y
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