Dynein light chain 1 induces assembly of large Bim complexes on mitochondria that stabilize Mcl-1 and regulate apoptosis

The Bcl-2 family protein Bim triggers mitochondrial apoptosis. Bim is expressed in nonapoptotic cells at the mitochondrial outer membrane, where it is activated by largely unknown mechanisms. We found that Bim is regulated by formation of large protein complexes containing dynein light chain 1 (DLC1...

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Detalhes bibliográficos
Publicado no:Genes Dev
Main Authors: Singh, Prafull Kumar, Roukounakis, Aristomenis, Frank, Daniel O., Kirschnek, Susanne, Das, Kushal Kumar, Neumann, Simon, Madl, Josef, Römer, Winfried, Zorzin, Carina, Borner, Christoph, Haimovici, Aladin, Garcia-Saez, Ana, Weber, Arnim, Häcker, Georg
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory Press 2017
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5666674/
https://ncbi.nlm.nih.gov/pubmed/28982759
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.302497.117
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