REGγ ablation impedes dedifferentiation of anaplastic thyroid carcinoma and accentuates radio-therapeutic response by regulating the Smad7-TGF-β pathway

Anaplastic thyroid cancer (ATC) is the most aggressive human thyroid malignancy, characterized by dedifferentiation and resistance to radioiodine therapy. The underlying mechanisms regulating ATC dedifferentiation are largely unknown. Here, we show that REGγ, a noncanonical proteasome activator high...

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Veröffentlicht in:Cell Death Differ
Hauptverfasser: Jiao, Chan, Li, Lin, Zhang, Pei, Zhang, Li, Li, Ke, Fang, Riqun, Yuan, Lei, Shi, Kaixuan, Pan, Linan, Guo, Qiannan, Gao, Xiao, Chen, Geng, Xu, Shichen, Wang, Qingwei, Zuo, Di, Wu, Wei, Qiao, Shanlou, Wang, Xiaoshuang, Moses, Robb, Xiao, Jianru, Li, Lei, Dang, Yongyan, Li, Xiaotao
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group UK 2019
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7205985/
https://ncbi.nlm.nih.gov/pubmed/31243343
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41418-019-0367-9
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