REGγ ablation impedes dedifferentiation of anaplastic thyroid carcinoma and accentuates radio-therapeutic response by regulating the Smad7-TGF-β pathway

Anaplastic thyroid cancer (ATC) is the most aggressive human thyroid malignancy, characterized by dedifferentiation and resistance to radioiodine therapy. The underlying mechanisms regulating ATC dedifferentiation are largely unknown. Here, we show that REGγ, a noncanonical proteasome activator high...

תיאור מלא

שמור ב:
מידע ביבליוגרפי
הוצא לאור ב:Cell Death Differ
Main Authors: Jiao, Chan, Li, Lin, Zhang, Pei, Zhang, Li, Li, Ke, Fang, Riqun, Yuan, Lei, Shi, Kaixuan, Pan, Linan, Guo, Qiannan, Gao, Xiao, Chen, Geng, Xu, Shichen, Wang, Qingwei, Zuo, Di, Wu, Wei, Qiao, Shanlou, Wang, Xiaoshuang, Moses, Robb, Xiao, Jianru, Li, Lei, Dang, Yongyan, Li, Xiaotao
פורמט: Artigo
שפה:Inglês
יצא לאור: Nature Publishing Group UK 2019
נושאים:
Article
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC7205985/
https://ncbi.nlm.nih.gov/pubmed/31243343
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41418-019-0367-9
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