REGγ ablation impedes dedifferentiation of anaplastic thyroid carcinoma and accentuates radio-therapeutic response by regulating the Smad7-TGF-β pathway

Anaplastic thyroid cancer (ATC) is the most aggressive human thyroid malignancy, characterized by dedifferentiation and resistance to radioiodine therapy. The underlying mechanisms regulating ATC dedifferentiation are largely unknown. Here, we show that REGγ, a noncanonical proteasome activator high...

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Detalhes bibliográficos
Publicado no:Cell Death Differ
Main Authors: Jiao, Chan, Li, Lin, Zhang, Pei, Zhang, Li, Li, Ke, Fang, Riqun, Yuan, Lei, Shi, Kaixuan, Pan, Linan, Guo, Qiannan, Gao, Xiao, Chen, Geng, Xu, Shichen, Wang, Qingwei, Zuo, Di, Wu, Wei, Qiao, Shanlou, Wang, Xiaoshuang, Moses, Robb, Xiao, Jianru, Li, Lei, Dang, Yongyan, Li, Xiaotao
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7205985/
https://ncbi.nlm.nih.gov/pubmed/31243343
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41418-019-0367-9
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