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The MAP3K13-TRIM25-FBXW7α axis affects c-Myc protein stability and tumor development
c-Myc (Myc) is a master transcription factor that is often deregulated and highly expressed by at least 50% of cancers. In many cases, Myc protein levels correlate with resistance to therapy and poor prognosis. However, effective direct inhibition of Myc by pharmacologic approaches has remained unac...
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| Опубликовано в: : | Cell Death Differ |
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| Главные авторы: | , , , , , , |
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
Nature Publishing Group UK
2019
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7205897/ https://ncbi.nlm.nih.gov/pubmed/31186535 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41418-019-0363-0 |
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