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The deubiquitinase USP21 stabilizes MEK2 to promote tumor growth

Deubiquitinases (DUBs) play essential roles in normal cell proliferation and tumor growth. However, the molecular mechanisms of DUBs on hepatocellular carcinoma (HCC) remains largely unknown. In this study, based on analysis of several HCC datasets, we found that the USP21 gene, which encodes a memb...

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Detalhes bibliográficos
Publicado no:Cell Death Dis
Main Authors: Li, Wenjuan, Cui, Kaisa, Prochownik, Edward V, Li, Youjun
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5924753/
https://ncbi.nlm.nih.gov/pubmed/29706623
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41419-018-0523-z
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