microRNA-206 impairs c-Myc-driven cancer in a synthetic lethal manner by directly inhibiting MAP3K13

c-Myc (Myc) is one of the most frequently dysregulated oncogenic transcription factors in human cancer. By functionally screening a microRNA (miR) library, we identified miR-206 as being a synthetic lethal in Myc over-expressing human cancer cells. miR-206 inhibited MAP3K13, which resulted in Myc pr...

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發表在:Oncotarget
Main Authors: Han, Han, Chen, Yuxing, Cheng, Li, Prochownik, Edward V., Li, Youjun
格式: Artigo
語言:Inglês
出版: Impact Journals LLC 2016
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Research Paper
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC4941324/
https://ncbi.nlm.nih.gov/pubmed/26918941
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.7653
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