Guttiferone K impedes cell cycle re-entry of quiescent prostate cancer cells via stabilization of FBXW7 and subsequent c-MYC degradation

Cell cycle re-entry by quiescent cancer cells is an important mechanism for cancer progression. While high levels of c-MYC expression are sufficient for cell cycle re-entry, the modality to block c-MYC expression, and subsequent cell cycle re-entry, is limited. Using reversible quiescence rendered b...

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Detalhes bibliográficos
Publicado no:Cell Death Dis
Main Authors: Xi, Z, Yao, M, Li, Y, Xie, C, Holst, J, Liu, T, Cai, S, Lao, Y, Tan, H, Xu, H-X, Dong, Q
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5143372/
https://ncbi.nlm.nih.gov/pubmed/27253416
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2016.123
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