A high-fat diet delays plasmin generation in a thrombomodulin-dependent manner in mice

Obesity is a prevalent prothrombotic risk factor marked by enhanced fibrin formation and suppressed fibrinolysis. Fibrin both promotes thrombotic events and drives obesity pathophysiology, but a lack of essential analytical tools has left fibrinolytic mechanisms affected by obesity poorly defined. U...

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Dettagli Bibliografici
Pubblicato in:Blood
Autori principali: Miszta, Adam, Kopec, Anna K., Pant, Asmita, Holle, Lori A., Byrnes, James R., Lawrence, Daniel A., Hansen, Kirk C., Flick, Matthew J., Luyendyk, James P., de Laat, Bas, Wolberg, Alisa S.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society of Hematology 2020
Soggetti:
Thrombosis and Hemostasis
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7205812/
https://ncbi.nlm.nih.gov/pubmed/32315384
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood.2019004267
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