Translation of HDAC6 PET imaging using [(18)F]EKZ-001 – cGMP production and measurement of HDAC6 target occupancy in NHPs

Histone deacetylase 6 (HDAC6) is a multifunctional cytoplasmic enzyme involved in diverse cellular processes such as intracellular transport and protein quality control. Inhibition of HDAC6 can alleviate defects in cell and rodent models of certain diseases, particularly neurodegenerative disorders,...

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Bibliografski detalji
Izdano u:ACS Chem Neurosci
Glavni autori: Celen, Sofie, Rokka, Johanna, Gilbert, Tonya M., Koole, Michel, Vermeulen, Isabeau, Serdons, Kim, Schroeder, Frederick A., Wagner, Florence F., Bleeser, Tom, Hightower, Baileigh G., Hu, Jiyun, Rahal, Dania, Beyzavi, M. Hassan, Vanduffel, Wim, Van Laere, Koen, Kranz, Janice E., Hooker, Jacob M., Bormans, Guy, Cawthorne, Christopher J.
Format: Artigo
Jezik:Inglês
Izdano: 2020
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Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7205522/
https://ncbi.nlm.nih.gov/pubmed/32159328
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschemneuro.0c00074
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