Clinical validation of the novel HDAC6 radiotracer [(18)F]EKZ-001 in the human brain

PURPOSE: Histone deacetylase 6 (HDAC6) is a cytoplasmic enzyme that modulates intracellular transport and protein quality control. Inhibition of HDAC6 deacetylase activity has shown beneficial effects in disease models, including Alzheimer’s disease and amyotrophic lateral sclerosis. This first-in-h...

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Enregistré dans:
Détails bibliographiques
Publié dans:Eur J Nucl Med Mol Imaging
Auteurs principaux: Koole, Michel, Van Weehaeghe, Donatienne, Serdons, Kim, Herbots, Marissa, Cawthorne, Christopher, Celen, Sofie, Schroeder, Frederick A., Hooker, Jacob M., Bormans, Guy, de Hoon, Jan, Kranz, Janice E., Van Laere, Koen, Gilbert, Tonya M.
Format: Artigo
Langue:Inglês
Publié: Springer Berlin Heidelberg 2020
Sujets:
Original Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7835181/
https://ncbi.nlm.nih.gov/pubmed/32638097
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00259-020-04891-y
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