Clinical validation of the novel HDAC6 radiotracer [(18)F]EKZ-001 in the human brain

PURPOSE: Histone deacetylase 6 (HDAC6) is a cytoplasmic enzyme that modulates intracellular transport and protein quality control. Inhibition of HDAC6 deacetylase activity has shown beneficial effects in disease models, including Alzheimer’s disease and amyotrophic lateral sclerosis. This first-in-h...

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Detalhes bibliográficos
Publicado no:Eur J Nucl Med Mol Imaging
Main Authors: Koole, Michel, Van Weehaeghe, Donatienne, Serdons, Kim, Herbots, Marissa, Cawthorne, Christopher, Celen, Sofie, Schroeder, Frederick A., Hooker, Jacob M., Bormans, Guy, de Hoon, Jan, Kranz, Janice E., Van Laere, Koen, Gilbert, Tonya M.
Formato: Artigo
Idioma:Inglês
Publicado em: Springer Berlin Heidelberg 2020
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7835181/
https://ncbi.nlm.nih.gov/pubmed/32638097
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00259-020-04891-y
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