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Clinical validation of the novel HDAC6 radiotracer [(18)F]EKZ-001 in the human brain
PURPOSE: Histone deacetylase 6 (HDAC6) is a cytoplasmic enzyme that modulates intracellular transport and protein quality control. Inhibition of HDAC6 deacetylase activity has shown beneficial effects in disease models, including Alzheimer’s disease and amyotrophic lateral sclerosis. This first-in-h...
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| Publié dans: | Eur J Nucl Med Mol Imaging |
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| Auteurs principaux: | , , , , , , , , , , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
Springer Berlin Heidelberg
2020
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7835181/ https://ncbi.nlm.nih.gov/pubmed/32638097 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00259-020-04891-y |
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