Translation of HDAC6 PET imaging using [(18)F]EKZ-001 – cGMP production and measurement of HDAC6 target occupancy in NHPs

Histone deacetylase 6 (HDAC6) is a multifunctional cytoplasmic enzyme involved in diverse cellular processes such as intracellular transport and protein quality control. Inhibition of HDAC6 can alleviate defects in cell and rodent models of certain diseases, particularly neurodegenerative disorders,...

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Xehetasun bibliografikoak
Argitaratua izan da:ACS Chem Neurosci
Egile Nagusiak: Celen, Sofie, Rokka, Johanna, Gilbert, Tonya M., Koole, Michel, Vermeulen, Isabeau, Serdons, Kim, Schroeder, Frederick A., Wagner, Florence F., Bleeser, Tom, Hightower, Baileigh G., Hu, Jiyun, Rahal, Dania, Beyzavi, M. Hassan, Vanduffel, Wim, Van Laere, Koen, Kranz, Janice E., Hooker, Jacob M., Bormans, Guy, Cawthorne, Christopher J.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 2020
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC7205522/
https://ncbi.nlm.nih.gov/pubmed/32159328
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschemneuro.0c00074
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