Translation of HDAC6 PET imaging using [(18)F]EKZ-001 – cGMP production and measurement of HDAC6 target occupancy in NHPs

Histone deacetylase 6 (HDAC6) is a multifunctional cytoplasmic enzyme involved in diverse cellular processes such as intracellular transport and protein quality control. Inhibition of HDAC6 can alleviate defects in cell and rodent models of certain diseases, particularly neurodegenerative disorders,...

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Publicado no:ACS Chem Neurosci
Main Authors: Celen, Sofie, Rokka, Johanna, Gilbert, Tonya M., Koole, Michel, Vermeulen, Isabeau, Serdons, Kim, Schroeder, Frederick A., Wagner, Florence F., Bleeser, Tom, Hightower, Baileigh G., Hu, Jiyun, Rahal, Dania, Beyzavi, M. Hassan, Vanduffel, Wim, Van Laere, Koen, Kranz, Janice E., Hooker, Jacob M., Bormans, Guy, Cawthorne, Christopher J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7205522/
https://ncbi.nlm.nih.gov/pubmed/32159328
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschemneuro.0c00074
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