Pancreas tissue slices from organ donors enable in situ analysis of type 1 diabetes pathogenesis

In type 1 diabetes (T1D), autoimmune destruction of pancreatic β cells leads to insulin deficiency and loss of glycemic control. However, knowledge about human pancreas pathophysiology in T1D remains incomplete. To address this limitation, we established a pancreas tissue slice platform of donor org...

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Vydáno v:JCI Insight
Hlavní autoři: Panzer, Julia K., Hiller, Helmut, Cohrs, Christian M., Almaça, Joana, Enos, Stephen J., Beery, Maria, Cechin, Sirlene, Drotar, Denise M., Weitz, John R., Santini, Jorge, Huber, Mollie K., Muhammad Fahd Qadir, Mirza, Pastori, Ricardo L., Domínguez-Bendala, Juan, Phelps, Edward A., Atkinson, Mark A., Pugliese, Alberto, Caicedo, Alejandro, Kusmartseva, Irina, Speier, Stephan
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Clinical Investigation 2020
Témata:
Technical Advance
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7205437/
https://ncbi.nlm.nih.gov/pubmed/32324170
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.134525
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