Pancreas tissue slices from organ donors enable in situ analysis of type 1 diabetes pathogenesis

In type 1 diabetes (T1D), autoimmune destruction of pancreatic β cells leads to insulin deficiency and loss of glycemic control. However, knowledge about human pancreas pathophysiology in T1D remains incomplete. To address this limitation, we established a pancreas tissue slice platform of donor org...

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Veröffentlicht in:JCI Insight
Hauptverfasser: Panzer, Julia K., Hiller, Helmut, Cohrs, Christian M., Almaça, Joana, Enos, Stephen J., Beery, Maria, Cechin, Sirlene, Drotar, Denise M., Weitz, John R., Santini, Jorge, Huber, Mollie K., Muhammad Fahd Qadir, Mirza, Pastori, Ricardo L., Domínguez-Bendala, Juan, Phelps, Edward A., Atkinson, Mark A., Pugliese, Alberto, Caicedo, Alejandro, Kusmartseva, Irina, Speier, Stephan
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Clinical Investigation 2020
Schlagworte:
Technical Advance
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7205437/
https://ncbi.nlm.nih.gov/pubmed/32324170
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.134525
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