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Opposite Roles of δ- and μ-Opioid Receptors in BACE1 Regulation and Alzheimer’s Injury

Alzheimer’s disease (AD) is characterized by amyloid plaques and neurofibrillary tangles. Substantial evidence for AD pathogenesis suggests that β-site APP cleaving enzyme 1 (BACE1) and γ-secretase enzyme initiate the amyloidogenic pathway and produces toxic Aβ peptides that prone to aggregate in th...

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Publicat a:Front Cell Neurosci
Autors principals: Xu, Yuan, Zhi, Feng, Balboni, Gianfranco, Yang, Yilin, Xia, Ying
Format: Artigo
Idioma:Inglês
Publicat: Frontiers Media S.A. 2020
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7204847/
https://ncbi.nlm.nih.gov/pubmed/32425755
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fncel.2020.00088
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