Cytochrome P450 Epoxygenase-Dependent Activation of TRPV4 Channel Participates in Enhanced Serotonin-Induced Pulmonary Vasoconstriction in Chronic Hypoxic Pulmonary Hypertension

Transient receptor potential vanilloid 4 (TRPV4) is a multi-functional non-selective channel expressed in pulmonary vasculatures. TRPV4 contributes to serotonin- (5-HT-) induced pulmonary vasoconstriction and is responsible in part for the enhanced 5-HT response in pulmonary arteries (PAs) of chroni...

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Bibliographic Details
Published in:Anal Cell Pathol (Amst)
Main Authors: Xia, Yang, Xia, Lexin, Jin, Zhou, Jin, Rui, Paudel, Omkar, Sham, James S. K.
Format: Artigo
Language:Inglês
Published: Hindawi 2020
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7204149/
https://ncbi.nlm.nih.gov/pubmed/32399392
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2020/8927381
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