TRPV4 channel contributes to serotonin-induced pulmonary vasoconstriction and the enhanced vascular reactivity in chronic hypoxic pulmonary hypertension

Transient receptor potential vanilloid 4 (TRPV4) is a mechanosensitive channel in pulmonary arterial smooth muscle cells (PASMCs). Its upregulation by chronic hypoxia is associated with enhanced myogenic tone, and genetic deletion of trpv4 suppresses the development of chronic hypoxic pulmonary hype...

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Détails bibliographiques
Auteurs principaux: Xia, Yang, Fu, Zhenzhen, Hu, Jinxing, Huang, Chun, Paudel, Omkar, Cai, Shaoxi, Liedtke, Wolfgang, Sham, James S. K.
Format: Artigo
Langue:Inglês
Publié: American Physiological Society 2013
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Articles
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3798671/
https://ncbi.nlm.nih.gov/pubmed/23739180
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpcell.00099.2013
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