TRPV4 channel contributes to serotonin-induced pulmonary vasoconstriction and the enhanced vascular reactivity in chronic hypoxic pulmonary hypertension

Transient receptor potential vanilloid 4 (TRPV4) is a mechanosensitive channel in pulmonary arterial smooth muscle cells (PASMCs). Its upregulation by chronic hypoxia is associated with enhanced myogenic tone, and genetic deletion of trpv4 suppresses the development of chronic hypoxic pulmonary hype...

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Detalhes bibliográficos
Main Authors: Xia, Yang, Fu, Zhenzhen, Hu, Jinxing, Huang, Chun, Paudel, Omkar, Cai, Shaoxi, Liedtke, Wolfgang, Sham, James S. K.
Formato: Artigo
Idioma:Inglês
Publicado em: American Physiological Society 2013
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3798671/
https://ncbi.nlm.nih.gov/pubmed/23739180
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpcell.00099.2013
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