TRPV4 channel contributes to serotonin-induced pulmonary vasoconstriction and the enhanced vascular reactivity in chronic hypoxic pulmonary hypertension

Transient receptor potential vanilloid 4 (TRPV4) is a mechanosensitive channel in pulmonary arterial smooth muscle cells (PASMCs). Its upregulation by chronic hypoxia is associated with enhanced myogenic tone, and genetic deletion of trpv4 suppresses the development of chronic hypoxic pulmonary hype...

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Autori principali: Xia, Yang, Fu, Zhenzhen, Hu, Jinxing, Huang, Chun, Paudel, Omkar, Cai, Shaoxi, Liedtke, Wolfgang, Sham, James S. K.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Physiological Society 2013
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Articles
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3798671/
https://ncbi.nlm.nih.gov/pubmed/23739180
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpcell.00099.2013
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