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On the use of DNA as a linker in antibody-drug conjugates: synthesis, stability and in vitro potency
Here we present the synthesis and evaluation of antibody-drug conjugates (ADCs), for which antibody and drug are non-covalently connected using complementary DNA linkers. These ADCs are composed of trastuzumab, an antibody targeting HER2 receptors overexpressed on breast cancer cells, and monomethyl...
Zapisane w:
| Wydane w: | Sci Rep |
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| Główni autorzy: | , , , , , , , , , , , |
| Format: | Artigo |
| Język: | Inglês |
| Wydane: |
Nature Publishing Group UK
2020
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| Hasła przedmiotowe: | |
| Dostęp online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7203131/ https://ncbi.nlm.nih.gov/pubmed/32376903 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-64518-y |
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