On the use of DNA as a linker in antibody-drug conjugates: synthesis, stability and in vitro potency

Here we present the synthesis and evaluation of antibody-drug conjugates (ADCs), for which antibody and drug are non-covalently connected using complementary DNA linkers. These ADCs are composed of trastuzumab, an antibody targeting HER2 receptors overexpressed on breast cancer cells, and monomethyl...

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Udgivet i:Sci Rep
Main Authors: Dovgan, Igor, Ehkirch, Anthony, Lehot, Victor, Kuhn, Isabelle, Koniev, Oleksandr, Kolodych, Sergii, Hentz, Alexandre, Ripoll, Manon, Ursuegui, Sylvain, Nothisen, Marc, Cianférani, Sarah, Wagner, Alain
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2020
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7203131/
https://ncbi.nlm.nih.gov/pubmed/32376903
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-64518-y
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