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Reduction–rebridging strategy for the preparation of ADPN-based antibody–drug conjugates

The reduction–rebridging strategy is a powerful method for the preparation of stable and homogeneous antibody–drug conjugates (ADCs). In this communication, we describe the development of the arylene-dipropiolonitrile (ADPN) functional group for the rebridging of reduced disulphide bonds and its app...

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Detalhes bibliográficos
Publicado no:Medchemcomm
Main Authors: Koniev, Oleksandr, Dovgan, Igor, Renoux, Brigitte, Ehkirch, Anthony, Eberova, Jitka, Cianférani, Sarah, Kolodych, Sergii, Papot, Sébastien, Wagner, Alain
Formato: Artigo
Idioma:Inglês
Publicado em: Royal Society of Chemistry 2018
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6071946/
https://ncbi.nlm.nih.gov/pubmed/30108971
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c8md00141c
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