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Reduction–rebridging strategy for the preparation of ADPN-based antibody–drug conjugates
The reduction–rebridging strategy is a powerful method for the preparation of stable and homogeneous antibody–drug conjugates (ADCs). In this communication, we describe the development of the arylene-dipropiolonitrile (ADPN) functional group for the rebridging of reduced disulphide bonds and its app...
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| Yayımlandı: | Medchemcomm |
|---|---|
| Asıl Yazarlar: | , , , , , , , , |
| Materyal Türü: | Artigo |
| Dil: | Inglês |
| Baskı/Yayın Bilgisi: |
Royal Society of Chemistry
2018
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| Konular: | |
| Online Erişim: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6071946/ https://ncbi.nlm.nih.gov/pubmed/30108971 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c8md00141c |
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