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Reduction–rebridging strategy for the preparation of ADPN-based antibody–drug conjugates
The reduction–rebridging strategy is a powerful method for the preparation of stable and homogeneous antibody–drug conjugates (ADCs). In this communication, we describe the development of the arylene-dipropiolonitrile (ADPN) functional group for the rebridging of reduced disulphide bonds and its app...
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| Udgivet i: | Medchemcomm |
|---|---|
| Main Authors: | , , , , , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Royal Society of Chemistry
2018
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6071946/ https://ncbi.nlm.nih.gov/pubmed/30108971 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c8md00141c |
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