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Structural Basis for PPARα Activation by 1H-pyrazolo-[3,4-b]pyridine Derivatives
Small-molecule agonism of peroxisome proliferator-activated receptor α (PPARα), a ligand-activated transcriptional factor involved in regulating fatty acid metabolism, is an important approach for treating dyslipidemia. Here, we determined the structures of the ligand-binding domain (LBD) of PPARα i...
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| 出版年: | Sci Rep |
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| 主要な著者: | , , , , , , , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
Nature Publishing Group UK
2020
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7203124/ https://ncbi.nlm.nih.gov/pubmed/32376995 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-64527-x |
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