Structural Basis for PPARα Activation by 1H-pyrazolo-[3,4-b]pyridine Derivatives

Small-molecule agonism of peroxisome proliferator-activated receptor α (PPARα), a ligand-activated transcriptional factor involved in regulating fatty acid metabolism, is an important approach for treating dyslipidemia. Here, we determined the structures of the ligand-binding domain (LBD) of PPARα i...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Yoshida, Takuya, Oki, Hiroya, Doi, Michihiro, Fukuda, Syohei, Yuzuriha, Tomohiro, Tabata, Ryotaro, Ishimoto, Kenji, Kawahara, Kazuki, Ohkubo, Tadayasu, Miyachi, Hiroyuki, Doi, Takefumi, Tachibana, Keisuke
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7203124/
https://ncbi.nlm.nih.gov/pubmed/32376995
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-64527-x
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