Discovery of peroxisome proliferator–activated receptor α (PPARα) activators with a ligand-screening system using a human PPARα-expressing cell line

Peroxisome proliferator–activated receptor α (PPARα) is a ligand-activated transcription factor that belongs to the superfamily of nuclear hormone receptors. PPARα is mainly expressed in the liver, where it activates fatty acid oxidation and lipoprotein metabolism and improves plasma lipid profiles....

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Vydáno v:J Biol Chem
Hlavní autoři: Tachibana, Keisuke, Yuzuriha, Tomohiro, Tabata, Ryotaro, Fukuda, Syohei, Maegawa, Takashi, Takahashi, Rika, Tanimoto, Keiichi, Tsujino, Hirofumi, Nunomura, Kazuto, Lin, Bangzhong, Matsuura, Yoshiharu, Tanaka, Toshiya, Hamakubo, Takao, Sakai, Juro, Kodama, Tatsuhiko, Kobayashi, Tadayuki, Ishimoto, Kenji, Miyachi, Hiroyuki, Doi, Takefumi
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2018
Témata:
Gene Regulation
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6028958/
https://ncbi.nlm.nih.gov/pubmed/29764933
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.002077
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