Discovery of peroxisome proliferator–activated receptor α (PPARα) activators with a ligand-screening system using a human PPARα-expressing cell line

Peroxisome proliferator–activated receptor α (PPARα) is a ligand-activated transcription factor that belongs to the superfamily of nuclear hormone receptors. PPARα is mainly expressed in the liver, where it activates fatty acid oxidation and lipoprotein metabolism and improves plasma lipid profiles....

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Détails bibliographiques
Publié dans:J Biol Chem
Auteurs principaux: Tachibana, Keisuke, Yuzuriha, Tomohiro, Tabata, Ryotaro, Fukuda, Syohei, Maegawa, Takashi, Takahashi, Rika, Tanimoto, Keiichi, Tsujino, Hirofumi, Nunomura, Kazuto, Lin, Bangzhong, Matsuura, Yoshiharu, Tanaka, Toshiya, Hamakubo, Takao, Sakai, Juro, Kodama, Tatsuhiko, Kobayashi, Tadayuki, Ishimoto, Kenji, Miyachi, Hiroyuki, Doi, Takefumi
Format: Artigo
Langue:Inglês
Publié: American Society for Biochemistry and Molecular Biology 2018
Sujets:
Gene Regulation
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6028958/
https://ncbi.nlm.nih.gov/pubmed/29764933
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.002077
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