Splicing factor DHX15 affects tp53 and mdm2 expression via alternate splicing and promoter usage

DHX15, a DEAH box containing RNA helicase, is a splicing factor required for the last step of splicing. Recent studies identified a recurrent mutational hotspot, R222G, in DHX15 in ∼ 6% of acute myeloid leukemia (AML) patients that carry the fusion protein RUNX1-RUNX1T1 produced by t (8;21) (q22;q22...

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Detalhes bibliográficos
Publicado no:Hum Mol Genet
Main Authors: McElderry, John, Carrington, Blake, Bishop, Kevin, Kim, Erika, Pei, Wuhong, Chen, Zelin, Ramanagoudr-Bhojappa, Ramanagouda, Prakash, Anupam, Burgess, Shawn M, Liu, P Paul, Sood, Raman
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2019
Assuntos:
General Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7202622/
https://ncbi.nlm.nih.gov/pubmed/31691804
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddz261
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