Multiplexed CRISPR/Cas9-mediated knockout of 19 Fanconi anemia pathway genes in zebrafish revealed their roles in growth, sexual development and fertility

Fanconi Anemia (FA) is a genomic instability syndrome resulting in aplastic anemia, developmental abnormalities, and predisposition to hematological and other solid organ malignancies. Mutations in genes that encode proteins of the FA pathway fail to orchestrate the repair of DNA damage caused by DN...

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Detalhes bibliográficos
Publicado no:PLoS Genet
Main Authors: Ramanagoudr-Bhojappa, Ramanagouda, Carrington, Blake, Ramaswami, Mukundhan, Bishop, Kevin, Robbins, Gabrielle M., Jones, MaryPat, Harper, Ursula, Frederickson, Stephen C., Kimble, Danielle C., Sood, Raman, Chandrasekharappa, Settara C.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2018
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6328202/
https://ncbi.nlm.nih.gov/pubmed/30540754
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1007821
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