Multiplexed CRISPR/Cas9-mediated knockout of 19 Fanconi anemia pathway genes in zebrafish revealed their roles in growth, sexual development and fertility

Fanconi Anemia (FA) is a genomic instability syndrome resulting in aplastic anemia, developmental abnormalities, and predisposition to hematological and other solid organ malignancies. Mutations in genes that encode proteins of the FA pathway fail to orchestrate the repair of DNA damage caused by DN...

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Dettagli Bibliografici
Pubblicato in:PLoS Genet
Autori principali: Ramanagoudr-Bhojappa, Ramanagouda, Carrington, Blake, Ramaswami, Mukundhan, Bishop, Kevin, Robbins, Gabrielle M., Jones, MaryPat, Harper, Ursula, Frederickson, Stephen C., Kimble, Danielle C., Sood, Raman, Chandrasekharappa, Settara C.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2018
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6328202/
https://ncbi.nlm.nih.gov/pubmed/30540754
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1007821
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