New Chirally Modified Bisphosphonates for Synthesis of Individual Beta,Gamma-CHX-Deoxynucleotide Diastereomers

Individual diastereomers of CXY bisphosphonate analogues of dNTPs or NTPs are useful chemical stereoprobes to investigate interactions within the chiral active site environment of enzymes such as polymerases and kinases. We previously reported synthetic access to β,γ-CHX-dGTPs (X = F or Cl) via a bi...

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Vydáno v:Phosphorus Sulfur Silicon Relat Elem
Hlavní autoři: Haratipour, Pouya, Minard, Corinne, Nakhjiri, Maryam, Negahbani, Amirsoheil, Kashemirov, Boris A., McKenna, Charles E.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2019
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7202557/
https://ncbi.nlm.nih.gov/pubmed/32377060
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/10426507.2018.1540482
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