Suppression of Ca(2+) signals by EGR4 controls Th1 differentiation and anti‐cancer immunity in vivo

While the zinc finger transcription factors EGR1, EGR2, and EGR3 are recognized as critical for T‐cell function, the role of EGR4 remains unstudied. Here, we show that EGR4 is rapidly upregulated upon TCR engagement, serving as a critical “brake” on T‐cell activation. Hence, TCR engagement of EGR4(−...

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Detalhes bibliográficos
Publicado no:EMBO Rep
Main Authors: Mookerjee‐Basu, Jayati, Hooper, Robert, Gross, Scott, Schultz, Bryant, Go, Christina K, Samakai, Elsie, Ladner, Jonathan, Nicolas, Emmanuelle, Tian, Yuanyuan, Zhou, Bo, Zaidi, M Raza, Tourtellotte, Warren, He, Shan, Zhang, Yi, Kappes, Dietmar J, Soboloff, Jonathan
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2020
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7202224/
https://ncbi.nlm.nih.gov/pubmed/32212315
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embr.201948904
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