Pro-inflammatory activation following demyelination is required for myelin clearance and oligodendrogenesis

Remyelination requires innate immune system function, but how exactly microglia and macrophages clear myelin debris after injury and tailor a specific regenerative response is unclear. Here, we asked whether pro-inflammatory microglial/macrophage activation is required for this process. We establish...

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Pubblicato in:J Exp Med
Autori principali: Cunha, Maria Inês, Su, Minhui, Cantuti-Castelvetri, Ludovico, Müller, Stephan A., Schifferer, Martina, Djannatian, Minou, Alexopoulos, Ioannis, van der Meer, Franziska, Winkler, Anne, van Ham, Tjakko J., Schmid, Bettina, Lichtenthaler, Stefan F., Stadelmann, Christine, Simons, Mikael
Natura: Artigo
Lingua:Inglês
Pubblicazione: Rockefeller University Press 2020
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7201919/
https://ncbi.nlm.nih.gov/pubmed/32078678
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20191390
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