Loss of Myelin Basic Protein Function Triggers Myelin Breakdown in Models of Demyelinating Diseases

Breakdown of myelin sheaths is a pathological hallmark of several autoimmune diseases of the nervous system. We employed autoantibody-mediated animal models of demyelinating diseases, including a rat model of neuromyelitis optica (NMO), to target myelin and found that myelin lamellae are broken down...

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Published in:Cell Rep
Main Authors: Weil, Marie-Theres, Möbius, Wiebke, Winkler, Anne, Ruhwedel, Torben, Wrzos, Claudia, Romanelli, Elisa, Bennett, Jeffrey L., Enz, Lukas, Goebels, Norbert, Nave, Klaus-Armin, Kerschensteiner, Martin, Schaeren-Wiemers, Nicole, Stadelmann, Christine, Simons, Mikael
Format: Artigo
Language:Inglês
Published: Cell Press 2016
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4949381/
https://ncbi.nlm.nih.gov/pubmed/27346352
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2016.06.008
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