Modulation of human platelet activation and in vivo vascular thrombosis by columbianadin: regulation by integrin α(IIb)β(3) inside-out but not outside-in signals

BACKGROUND: Columbianadin (CBN) is one of the main coumarin constituents isolated from Angelica pubescens. The pharmacological value of CBN is well demonstrated, especially in the prevention of several cancers and analgesic activity. A striking therapeutic target for arterial thrombosis is inhibitio...

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Detalhes bibliográficos
Publicado no:J Biomed Sci
Main Authors: Hou, Shaw-Min, Hsia, Chih-Wei, Tsai, Cheng-Lin, Hsia, Chih-Hsuan, Jayakumar, Thanasekaran, Velusamy, Marappan, Sheu, Joen-Rong
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2020
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7201758/
https://ncbi.nlm.nih.gov/pubmed/32375785
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12929-020-0619-5
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