Urine Tenofovir Concentrations Correlate With Plasma and Relate to Tenofovir Disoproxil Fumarate Adherence: A Randomized, Directly Observed Pharmacokinetic Trial (TARGET Study)

BACKGROUND: Direct measurement of tenofovir (TFV) in urine could be an objective measure to monitor adherence to preexposure prophylaxis (PrEP) or TFV-based antiretroviral therapy (ART). METHODS: We conducted a 3-arm randomized, pharmacokinetic study of tenofovir disoproxil fumarate (TDF) 300 mg/emt...

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Veröffentlicht in:Clin Infect Dis
Hauptverfasser: Drain, Paul K, Kubiak, Rachel W, Siriprakaisil, Oraphan, Klinbuayaem, Virat, Quame-Amaglo, Justice, Sukrakanchana, Pra-Ornsuda, Tanasri, Suriyan, Punyati, Pimpinun, Sirirungsi, Wasna, Cressey, Ratchada, Bacchetti, Peter, Okochi, Hideaki, Baeten, Jared M, Gandhi, Monica, Cressey, Tim R
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2020
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Articles and Commentaries
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7201421/
https://ncbi.nlm.nih.gov/pubmed/31314073
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/cid/ciz645
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