Lymphocyte DNA methylation mediates genetic risk at shared immune-mediated disease loci

BACKGROUND: Defining regulatory mechanisms through which noncoding risk variants influence the cell-mediated pathogenesis of immune-mediated disease (IMD) has emerged as a priority in the post–genome-wide association study era. OBJECTIVES: With a focus on rheumatoid arthritis, we sought new insight...

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Udgivet i:J Allergy Clin Immunol
Main Authors: Clark, Alexander D., Nair, Nisha, Anderson, Amy E., Thalayasingam, Nishanthi, Naamane, Najib, Skelton, Andrew J., Diboll, Julie, Barton, Anne, Eyre, Stephen, Isaacs, John D., Pratt, Arthur G., Reynard, Louise N.
Format: Artigo
Sprog:Inglês
Udgivet: Mosby 2020
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7201180/
https://ncbi.nlm.nih.gov/pubmed/31945409
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jaci.2019.12.910
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