IL-6 Mediated Transcriptional Programming of Naïve CD4+ T Cells in Early Rheumatoid Arthritis Drives Dysregulated Effector Function

Objective: We have previously shown that increased circulating interleukin-6 (IL-6) results in enhanced CD4+ T cell signaling via signal transduction and activator of transcription-3 (STAT3) in early rheumatoid arthritis (RA). We tested the hypothesis that transcriptional “imprinting” of T-cells by...

詳細記述

保存先:
書誌詳細
出版年:Front Immunol
主要な著者: Ridgley, Laura A., Anderson, Amy E., Maney, Nicola J., Naamane, Najib, Skelton, Andrew J., Lawson, Catherine A., Emery, Paul, Isaacs, John D., Carmody, Ruaidhrí J., Pratt, Arthur G.
フォーマット: Artigo
言語:Inglês
出版事項: Frontiers Media S.A. 2019
主題:
Immunology
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC6618050/
https://ncbi.nlm.nih.gov/pubmed/31333666
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2019.01535
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