Dual targeting of BCL2 and MCL1 rescues myeloma cells resistant to BCL2 and MCL1 inhibitors associated with the formation of BAX/BAK hetero-complexes

Multiple myeloma is a plasma cell malignancy that escapes from apoptosis by heterogeneously over-expressing anti-apoptotic BCL2 proteins. Myeloma cells with a t(11;14) translocation present a particular vulnerability to BCL2 inhibition while a majority of myeloma cells relies on MCL1 for survival. T...

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Publicat a:Cell Death Dis
Autors principals: Seiller, Carolane, Maiga, Sophie, Touzeau, Cyrille, Bellanger, Céline, Kervoëlen, Charlotte, Descamps, Géraldine, Maillet, Laurent, Moreau, Philippe, Pellat-Deceunynck, Catherine, Gomez-Bougie, Patricia, Amiot, Martine
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2020
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7200824/
https://ncbi.nlm.nih.gov/pubmed/32371863
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41419-020-2505-1
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