Targeting Oxidative Stress With Auranofin or Prima-1(Met) to Circumvent p53 or Bax/Bak Deficiency in Myeloma Cells

Prima-1(Met) (APR-246) was previously shown to be dependent on glutathione inhibition and on ROS induction in cancer cells with mutated or deleted TP53. Because this ROS induction was, at least in part, due to a direct interference with the thioredoxin reductase enzyme, we investigated whether activ...

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Detalhes bibliográficos
Publicado no:Front Oncol
Main Authors: Tessoulin, Benoit, Descamps, Geraldine, Dousset, Christelle, Amiot, Martine, Pellat-Deceunynck, Catherine
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2019
Assuntos:
Oncology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6414792/
https://ncbi.nlm.nih.gov/pubmed/30895171
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fonc.2019.00128
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