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Targeting Oxidative Stress With Auranofin or Prima-1(Met) to Circumvent p53 or Bax/Bak Deficiency in Myeloma Cells

Prima-1(Met) (APR-246) was previously shown to be dependent on glutathione inhibition and on ROS induction in cancer cells with mutated or deleted TP53. Because this ROS induction was, at least in part, due to a direct interference with the thioredoxin reductase enzyme, we investigated whether activ...

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Publicat a:Front Oncol
Autors principals: Tessoulin, Benoit, Descamps, Geraldine, Dousset, Christelle, Amiot, Martine, Pellat-Deceunynck, Catherine
Format: Artigo
Idioma:Inglês
Publicat: Frontiers Media S.A. 2019
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6414792/
https://ncbi.nlm.nih.gov/pubmed/30895171
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fonc.2019.00128
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