Biological rational for sequential targeting of Bruton tyrosine kinase and Bcl-2 to overcome CD40-induced ABT-199 resistance in mantle cell lymphoma

The aggressive biological behavior of mantle cell lymphoma (MCL) and its short response to current treatment highlight a great need for better rational therapy. Herein, we investigate the ability of ABT-199, the Bcl-2-selective BH3 mimetic, to kill MCL cells. Among MCL cell lines tested (n = 8), onl...

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Bibliografiske detaljer
Udgivet i:Oncotarget
Main Authors: Chiron, David, Dousset, Christelle, Brosseau, Carole, Touzeau, Cyrille, Maïga, Sophie, Moreau, Philippe, Pellat-Deceunynck, Catherine, Le Gouill, Steven, Amiot, Martine
Format: Artigo
Sprog:Inglês
Udgivet: Impact Journals LLC 2015
Fag:
Research Paper
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4496181/
https://ncbi.nlm.nih.gov/pubmed/25797245
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