Combination of lenalidomide with vitamin D3 induces apoptosis in mantle cell lymphoma via demethylation of BIK

Mantle cell lymphoma (MCL) is a currently incurable B-cell malignancy. Lenalidomide (Len) has been demonstrated to be one of the most efficient new treatment options. Because Len and 1α,25-dihydroxyvitamin (VD3) synergize to kill breast cancer cells, we investigated whether VD3 could increase the ab...

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Detalhes bibliográficos
Publicado no:Cell Death Dis
Main Authors: Brosseau, C, Dousset, C, Touzeau, C, Maïga, S, Moreau, P, Amiot, M, Le Gouill, S, Pellat-Deceunynck, C
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2014
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4454319/
https://ncbi.nlm.nih.gov/pubmed/25165875
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2014.346
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