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PBRM1 suppresses tumor growth as a novel p53 acetylation reader
The reader(s) for acetylated tumor antigen p53 remains elusive. Here, PBRM1 (polybromo-1) is identified as a reader for acetylated lysine382 on p53 through its bromodomain 4 (BD4). PBRM1 BD4 mutants fail to support p53 transcriptional activity and suppress tumor growth. Thus PBRM1 suppresses tumor g...
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| Publicado en: | Mol Cell Oncol |
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| Autores principales: | , , |
| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
Taylor & Francis
2020
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7199739/ https://ncbi.nlm.nih.gov/pubmed/32391422 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/23723556.2020.1729680 |
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